2,4-THIAZOLIDINEDIONE DERIVATIVES POSSESSING ANTIDIABETIC ACTIVITY I. (THEIR ANTIDIABETIC EFFECTS, STRUCTURE-ACTIVITY RELATIONSHIP AND METABOLISM)

Rahmiye ERTAN*°, Oya BOZDAG*

**Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Tandogan, Ankara, TURKEY.
°Corresponding Author

Summary:
The prototypical agent, Ciglizatone, a 5-(4-alkoxybenzyl)thiazolidine-2,4-dione, is a new antidiabetic agent structurally distinct from the sulfonylureas and biguanides.The investigations on these compounds which show antidiabetic activitiy by enhancing insulin sensivitiy are stil in progres.In this study,the antidiabetic effects, structure-activity relationship and metabolism of the recently developed 2,4-TZD derivatives were investigated.

Key words:
2,4-Thiazolidione derivatives, Antidiabetic agents, Structure-activity relationship, metabolism.