CELL BIOLOGY AND PHARMACOLOGY OF ADIPOSE TISSUE SECRETION

George N. CHALDAKOV*°,Marco FIORE**,Mariana HRISTOVA***,Luigi ALOE**

*Division of Electron Microscopy, Department of Forensic Medicine,Medical Universty, Varna, BULGARIA.
**Institue of Neurobiology, National Research Council, Rome, ITALY.
***Endocrinology Clinic, Municipal Hospital,Varna, BULGARIA.
°Corresponding Author

Summary:
Recent advences in cell biology provides evidence that adipose tissue cells,adipocytes and stromal fibroblasts,are bona fide secretory cells. That is,using endopara- and autocrine pathways, these cells synthesize and release a number of multifunctional molecules, including cytokines,growth factors,enzymes,and hormones.These are collectively named adipokines. To tackle the issue of pathobiology and therapy of adipokine-related diseases a sound knowledge of the cell biology and pharmacology of adipose tissue secretion is required.An update of this matter is reviewed here.Perspectives for studying roles of locally produced adipokines in the disease proces affecting the associated organ are also presented.We term this the adipose tissue-directed (adipotopic) approach in the study of pathobiology, prevention, and theraphy of disease.

Key words:
Adipose tissue, Adipocytes, Fibroblasts, Secretion, Adipokines, Disease, Pharmacology, Therapy.