SEPARATION OF ENANTIOMERS OF SOME CONDENSED DIHYDROPYRIMIDINE DERIVATIVES BY HPLC USING CHIRAL STATIONARY PHASES

Selma SARAÇ*, Birsen TOZKOPARAN*, Mevlüt ERTAN*°

*Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistrt, 06100 Sihhiye, Ankara ,TURKEY.
°Corresponding Author

Summary:
The separation of enantiomers of 2-benzylidene-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl ester derivatives by high performance liquid chromatography (HPLC) was studied using cellulose tris(3,5-dimetylphenylcarbamate) (OD) or cellulose tris(4-methylphenylcarbamate) (OG) as chiral stationary phases.The convenient methods for the preparation of OD and OG chiral stationary phases were described. Most of the compounds were effectively resolved into their enantiomers on these phenylcarbamates and the enantiomers were characterized by some chromatograpic data.

Key words:
2-Benzylidene-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]
pyrimidine-6-carboxylic acid methyl esters, Condensed dihydropyrimidine derivatives, Cellulose tris (3,5-dimethylphenylcarbamate), Enantioseparation, Chiral HPLC.