THE METHODS OF ISOLATION AND ANALYSIS OF THE TAXANE-TYPE DITERPENOIDS

Nurgün ERDEMOGLU*°, Bilge SENER*

*Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, 06330 Etiler, Ankara, TURKEY.
°Corresponding Author

Summary:
The taxane class diterpenoid taxol is important anticancer drug first isolated from the bark of the Pacific Yew tree (Taxus brevifolia Nutt.) in 1971. Its broad spectrum anticancer activity in clinical trials has spurred a worldwide search. During these researches, many taxane-type diterpenoids have been isolated from different Taxus species. In this paper, the methods of isolation and analysis of taxane-type diterpenoids from Taxus species have been reviewed.

Key words:
Taxus sp., Taxol, Taxoids, Diterpenoids, Antitumor agents.