INVESTIGATION ON THE VARIATION OF IN VITRO DISSOLUTION RATES AMONG THE BATCHES OF THE TABLETS CONTAINING FLUTAMIDE

Nursin GÖNÜL*°, Aysel ÖLÇER*, Tamer BAYKARA*, Özlem TAYGAL**

*Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Tandogan, Ankara, TURKEY.
** Sümer Pharmacy, SAMSUN.
°Corresponding Author

Summary:
Tablets containing flutamide are being imported to Turkey and available on the Turkish drug market. Flutamide tablets are specifically being used in the treatment of prostate cancer.
Only two different brands of flutamide tablets and a few batches belonging to them have already been available on the market.
In this study, the physical parameters and in vitro dissolution rates of flutamide tablets from three batches of two different brands were investigated. The dissolution behaviours of the drug released from the tablets were studied in proposed medium and in addition, in the gastrointestinal medium. According to the results obtained, the differences among the batches were evaluated. The results obtained indicated that all the tablets tested met the criteria specified by physical parameters. However a significant difference between the batches of F coded brand was found concerning the in vitro dissolution rate.

Key words:
Flutamide, Flutamide tablet, In vitro dissolution rate.