ANALYSIS OF SYRUPS CONTAINING CHLORPHENIRAMINE MALEATE, CODEINE PHOSPHATE AND EPHEDRINE HYDROCHLORIDE BY DERIVATIVE UV SPECTROPHOTOMETRY
Filiz SAYIN*, Sedef KIR*, Aytekin TEMIZER* °
*Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TURKEY.
°Corresponding Author

Summary:
A method was presented for the determination of chlorpheniramine maleate (I), codeine phosphate (II) and ephedrine hydrochloride (III) in a mixture of them without any separation step. The compounds I and II can be determined simultaneously by using the second derivative UV spectrophotometry. The compound III can be determined by the same method after the oxidation with sodium metaperiodate. The linear ranges of concentrations for the analysis of I, II and III have been found as 0.001-0.08, 0.001-0.4 and 0.005-1.80 rng/mL, respectively. The method developed was applied to pharmaceutical forms of these compounds. The percent recoveries were found as 101 % for I, 100 % for II and 100 % for III.

Keywords:
Derivative UV spectrophotometry, chlorpheniramine maleate, codeine phosphate and ephedrine h±ydrochloride, pharmaceutical preparations.