ENZYME-MEDIATED REGIOSELECTIVE ACYLATIONS OF FLAVONOID GLYCOSIDES

Ihsan ÇALIS*,o, Meltem ÖZIPEK*, Mevlüt ERTAN**, Peter RUEDI***

* Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Sihhiye, Ankara, TURKEY. **Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100 Sihhiye, Ankara, TURKEY. *** Universitaet Zürich, Organisch-Chemisches Institut, CH-8057 Zürich, SWITZERLAND.
oCorresponding Author

Summary:
Flavonoid glycosides, xanthorhamnins B, C, and rutin have been acylated by the catalytic action of the protease subtilisin in anhydrous pyridine. The acylation occurred with high yield with rutin giving a single monoester on its glucose moiety showing excellent selectivity. But it occurred with low yield on the galactose moiety of the two flavonoid triglycosides.

Key words:
Acylated flavonoid glycosides, Enzymatic acylation