Nilüfer TARIMCI*o, Neslihan Satiroglu-Tezcan*

*Ankara University, Faculty of Pharmacy, 06100 Tandogan, Ankara, TURKEY.
oCorresponding Author

Summary:
The tablet formulation of naproxen, which is a non-steroidal antiinflammatory agent, was studied. Twelve different formulations were prepared by wet granulation and direct compression technique. The effect of various adjuvants on the physico-pharmaceutical properties and release profiles of the substance were investigated. The dissolution data were fitted to several kinetic equations by employing a program (DISSOL) written for this purpose. It was seen that the wet granulation method was better than direct compression for poorly soluble naproxen. Primogel and CLD-2 were also found to be best disintegrants.